Across TCGA patient cohorts, PTP4A3 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTP4A3-associated genes across cancer lineages are PKC-a_pS657, Stathmin, and eEF2. Each is linked with PTP4A3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTP4A3-to-partner and partner-to-PTP4A3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTP4A3→partner) and Y-score (partner→PTP4A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-a_pS657 →	+0.319	+1.713	.049	.027	3	2
UCEC	Stathmin →	+0.131	+2.000	.025	.030	3	2
UCEC	eEF2 →	+0.320	+1.700	.035	.044	3	1
UCEC	MEK1 →	+0.485	+2.584	.001	.010	3	1
UCEC	p62 Lck ligand →	+0.462	+3.321	<.001	.009	3	1
UCEC	PDCD4 →	-0.613	-1.700	.002	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

PTP4A3 survival (RNA) · tumor vs normal (RNA) · all PTP4A3 data types