Across TCGA pan-cancer cohorts, PTP4A2 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated PTP4A2 data layer compared with 4 for mass-spec protein.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PTP4A2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PTP4A2 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SKCM show a favorable association.
KIRP, KICH, and LIHC are the cancer types where PTP4A2 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.