PTP4A1

Across TCGA patient cohorts, PTP4A1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,013 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PTP4A1-associated proteins across cancer lineages are ZNF703_S252, KDM2B_S1031, and APOC1. Each is linked with PTP4A1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PTP4A1-to-partner and partner-to-PTP4A1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTP4A1 versus ZNF703_S252 in PDAC, with a Pearson correlation of -0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PTP4A1→partner) and Y-score (partner→PTP4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ZNF703_S252 →	-1.235	-0.525	<.001	<.001	3	4
LSCC	KDM2B_S1031 →	-0.357	-0.406	.002	.004	3	3
GBM	APOC1 →	+0.559	+0.119	.001	.003	3	3
PDAC	PAK1_S174 →	-0.742	-0.438	<.001	<.001	3	3
LUAD	PDE3A_S520 →	+0.794	+0.582	<.001	<.001	3	3
GBM	PRPF38B_S529 →	-0.518	-0.166	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,013 associations by consensus.

PTP4A1 vs ZNF703_S252 — PDAC

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