PTP4A1

Across TCGA patient cohorts, PTP4A1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTP4A1-associated genes across cancer lineages are GAPDH, eEF2, and EGFR_pY1068. Each is linked with PTP4A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTP4A1-to-partner and partner-to-PTP4A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by PTP4A1-low versus PTP4A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTP4A1→partner) and Y-score (partner→PTP4A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.452	+1.502	.021	.030	3	2
UCEC	eEF2 →	+0.348	+2.321	.008	.033	3	1
UCEC	EGFR_pY1068 →	-0.335	-2.736	<.001	<.001	3	1
UCEC	eIF4E →	+0.161	+3.183	.038	.009	3	1
UCEC	A-Raf_pS299 →	-0.117	-2.807	.007	.003	3	1
UCEC	ERK2 →	+0.250	+2.247	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

GAPDH by PTP4A1 expression — UCEC

Explore this box plot interactively →