PTOV1

Across TCGA patient cohorts, PTOV1 mutation is significantly associated with the RNA expression of many other genes, with 971 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTOV1-associated genes across cancer lineages are RNA5SP414, CCL4, and RNA5SP412. Each is linked with PTOV1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTOV1-to-partner and partner-to-PTOV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by PTOV1-low versus PTOV1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTOV1→partner) and Y-score (partner→PTOV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+0.488	+1.892	<.001	.005	3	2
UCEC	CCL4 →	+1.012	+2.895	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.471	+1.879	<.001	.003	3	2
SKCM	RNU6-907P →	+0.430	+4.352	.001	.007	3	2
UCEC	H2AC4 →	+0.453	+2.403	.003	<.001	3	2
COAD	GNPNAT1 →	+0.983	+3.210	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 971 associations by consensus.

RNA5SP414 by PTOV1 expression — UCEC

Explore this box plot interactively →