PTOV1

Across TCGA patient cohorts, PTOV1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTOV1-associated genes across cancer lineages are TSC1, GATA3, and mTOR. Each is linked with PTOV1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTOV1-to-partner and partner-to-PTOV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSC1 grouped by PTOV1-low versus PTOV1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTOV1→partner) and Y-score (partner→PTOV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TSC1 →	-0.173	-1.960	.008	.029	3	3
UCEC	GATA3 →	+0.173	+1.691	.017	.014	3	2
UCEC	mTOR →	-0.195	-1.678	.001	.023	3	2
UCEC	PCNA →	+0.186	+1.678	.024	.023	3	2
UCEC	PKC-delta_pS664 →	-0.153	-1.990	<.001	.030	3	2
UCEC	ATM →	-0.600	-3.247	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

TSC1 by PTOV1 expression — UCEC

Explore this box plot interactively →