PTOV1

Across TCGA cell cohorts, PTOV1 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTOV1-associated genes across cancer lineages are RSPH6A, A4GNT, and GNMT. Each is linked with PTOV1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTOV1-to-partner and partner-to-PTOV1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RSPH6A grouped by PTOV1-low versus PTOV1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTOV1→partner) and Y-score (partner→PTOV1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RSPH6A →	+0.151	+3.688	<.001	.001	3	1
LARGE_INTESTINE	A4GNT →	+0.075	+2.807	<.001	.002	3	1
LARGE_INTESTINE	GNMT →	+0.287	+3.266	<.001	.005	3	1
LARGE_INTESTINE	BRDT →	+0.119	+4.392	<.001	<.001	3	1
LARGE_INTESTINE	CCDC54 →	+0.112	+3.000	<.001	.003	3	1
LARGE_INTESTINE	RITA1 →	+0.647	+3.215	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

RSPH6A by PTOV1 expression — LARGE_INTESTINE

Explore this box plot interactively →