PTMS

Across TCGA patient cohorts, PTMS RNA expression is significantly associated with the protein abundance of many other proteins, with 10,700 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible PTMS-associated proteins across cancer lineages are PTMS_S5, SAE1, and SMARCA5. Each is linked with PTMS in more than 5 cancer types. Because this analysis shows association rather than direction, both PTMS-to-partner and partner-to-PTMS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTMS versus PTMS_S5 in BRCA, with a Pearson correlation of 0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PTMS→partner) and Y-score (partner→PTMS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PTMS_S5 →	+0.720	+0.623	<.001	<.001	3	6
HNSC	SAE1 →	+0.260	+0.549	<.001	<.001	3	5
GBM	SMARCA5 →	+0.253	+0.406	.003	<.001	3	5
HNSC	SMC3 →	+0.263	+0.555	<.001	.003	3	5
GBM	BRD7 →	+0.205	+0.321	<.001	<.001	3	5
HNSC	DHX9 →	+0.191	+0.630	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,700 associations by consensus.

PTMS vs PTMS_S5 — BRCA

Explore this scatter interactively →