PTMS

Across TCGA patient cohorts, PTMS mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTMS-associated genes across cancer lineages are HSP70, p62 Lck ligand, and STAT3_pY705. Each is linked with PTMS in more than 1 cancer types. Because this analysis shows association rather than direction, both PTMS-to-partner and partner-to-PTMS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSP70 grouped by PTMS-low versus PTMS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTMS→partner) and Y-score (partner→PTMS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSP70 →	-0.509	-2.990	.015	.036	3	1
UCEC	p62 Lck ligand →	+0.410	+3.009	.016	.019	3	1
UCEC	STAT3_pY705 →	-0.470	-3.321	<.001	.010	3	1
UCEC	c-Kit →	-0.265	-3.321	.030	.010	1	1
UCEC	4E-BP1 →	+0.463	+3.321	.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

HSP70 by PTMS expression — UCEC

Explore this box plot interactively →