PTK2B

Across TCGA pan-cancer cohorts, PTK2B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PTK2B data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PTK2B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTK2B expression acts as an unfavorable survival marker.

COAD, PDAC, and HNSC are the cancer types where PTK2B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.911	1.000	.012	60	view →
PDAC	DFS	Tertile	III,IV	0.352	0.864	.009	17	view →
HNSC	DFS	Tertile	II,III,IV	0.873	0.971	.028	8	view →
LUAD	OS	Quartile	III,IV	0.427	0.993	.040	4	view →
LSCC	OS	Median	II,III,IV	0.628	0.854	.036	2	view →
CCRCC	DFS	Median	III,IV	0.763	0.947	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PTK2B–COAD (DFS)

Open the COAD breakdown →