PTK2

Across TCGA patient cohorts, PTK2 RNA expression is significantly associated with the protein abundance of many other proteins, with 17,343 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PTK2-associated proteins across cancer lineages are AGO2, SCRIB, and PYCR3. Each is linked with PTK2 in more than 7 cancer types. Because this analysis shows association rather than direction, both PTK2-to-partner and partner-to-PTK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTK2 versus AGO2 in BRCA, with a Pearson correlation of 0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PTK2→partner) and Y-score (partner→PTK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AGO2 →	+0.265	+0.575	<.001	<.001	3	8
BRCA	SCRIB →	+0.422	+0.645	<.001	<.001	3	8
BRCA	PYCR3 →	+0.493	+0.593	<.001	<.001	3	7
OV	YWHAZ →	+0.403	+0.561	.001	<.001	3	7
LSCC	NONO →	+0.156	+0.394	.004	.002	3	6
GBM	ARHGAP30 →	-0.502	-0.333	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,343 associations by consensus.

PTK2 vs AGO2 — BRCA

Explore this scatter interactively →