PTK2

Across TCGA patient cohorts, PTK2 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTK2-associated genes across cancer lineages are ATM, PCNA, and Caspase-7-cleavedD198. Each is linked with PTK2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PTK2-to-partner and partner-to-PTK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PTK2-low versus PTK2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTK2→partner) and Y-score (partner→PTK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.612	-2.991	.002	.036	3	4
UCEC	PCNA →	+0.218	+2.321	<.001	.005	3	3
UCEC	Caspase-7-cleavedD198 →	+0.686	+2.584	<.001	<.001	3	3
COAD	INPP4B →	-0.486	-2.991	.012	.036	3	3
UCEC	ERK2 →	+0.141	+1.906	.016	.014	3	2
UCEC	p27_pT198 →	+0.068	+1.064	.037	.048	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ATM by PTK2 expression — COAD

Explore this box plot interactively →