PTK2

Across TCGA cell cohorts, PTK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,261 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PTK2-associated GO terms across cancer lineages are Detection of muscle stretch, miRNA-mediated gene silencing by mRNA destabilization, and Protein monoubiquitination. Each is linked with PTK2 in more than 14 cancer types. Because this analysis shows association rather than direction, both PTK2-to-partner and partner-to-PTK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Detection of muscle stretch grouped by PTK2-low versus PTK2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTK2→partner) and Y-score (partner→PTK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Detection of muscle stretch →	+0.217	+1.146	.002	<.001	3	15
LUNG_SCLC	miRNA-mediated gene silencing by mRNA destabilization →	+0.182	+0.796	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Protein monoubiquitination →	+0.071	+0.975	<.001	<.001	3	11
BONE	Intracellular mRNA localization →	+0.121	+0.987	.001	.001	3	9
STOMACH	Response to oscillatory fluid shear stress →	+0.217	+1.467	<.001	.004	3	8
STOMACH	Cellular response to oscillatory fluid shear stress →	+0.217	+1.467	<.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,261 associations by consensus.

Detection of muscle stretch by PTK2 expression — BREAST

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