PTK2

Across TCGA cell cohorts, PTK2 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible PTK2-associated genes across cancer lineages are ZAN, TCF23, and KCNK10. Each is linked with PTK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTK2-to-partner and partner-to-PTK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZAN grouped by PTK2-low versus PTK2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTK2→partner) and Y-score (partner→PTK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZAN →	+0.027	+3.954	<.001	.005	3	2
BLOOD_Lymphoma	TCF23 →	+0.153	+3.523	<.001	.009	3	2
BLOOD_Myeloma	KCNK10 →	+0.218	+3.906	<.001	.009	3	1
BLOOD_Myeloma	ZP2 →	+0.092	+3.906	.003	.009	3	1
BLOOD_Myeloma	NPY →	+0.056	+3.906	<.001	.009	3	1
BLOOD_Myeloma	ZNF831 →	+0.202	+4.285	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

ZAN by PTK2 expression — BLOOD_Lymphoma

Explore this box plot interactively →