PTK2

Across TCGA cell cohorts, PTK2 mutation is significantly associated with the mutation status of many other genes, with 2,541 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTK2-associated genes across cancer lineages are KLHL32, VEPH1, and ESRP1. Each is linked with PTK2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PTK2-to-partner and partner-to-PTK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL32 grouped by PTK2-low versus PTK2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTK2→partner) and Y-score (partner→PTK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KLHL32 →	+4.977	+5.638	<.001	<.001	1	4
SKIN	VEPH1 →	+5.392	+4.824	.004	.004	1	4
LUNG_SCLC	ESRP1 →	+4.502	+5.066	.007	.007	1	4
OVARY	P4HB →	+5.415	+5.415	.004	.004	1	3
LUNG_SCLC	FAM71B →	+5.502	+5.502	.003	.003	1	3
SKIN	GRIK1 →	+5.392	+4.824	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,541 associations by consensus.

KLHL32 by PTK2 expression — SKIN

Explore this box plot interactively →