PTHLH

Across TCGA pan-cancer cohorts, PTHLH Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PTHLH data layer compared with 23 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in sarcoma (SARC), where higher PTHLH Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PTHLH expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SARC, CESC, and BRCA are the cancer types where PTHLH Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SARC	OS	Median	All	0.143	0.745	<.001	6	view →
CESC	OS	Median	All	0.271	0.798	.010	6	view →
BRCA	OS	Median	All	0.117	0.578	.019	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
COAD	DFS	Median	IV	0.035	0.501	<.001	6	view →
UCEC	DFS	Median	All	0.950	0.628	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PTHLH–SARC (OS)

Open the SARC breakdown →