PTHLH

Across TCGA patient cohorts, PTHLH mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTHLH-associated genes across cancer lineages are Akt_pT308, 14-3-3_beta, and GSK-3_pS9. Each is linked with PTHLH in more than 1 cancer types. Because this analysis shows association rather than direction, both PTHLH-to-partner and partner-to-PTHLH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Akt_pT308 grouped by PTHLH-low versus PTHLH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTHLH→partner) and Y-score (partner→PTHLH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.612	+2.999	.022	.035	3	2
UCEC	14-3-3_beta →	-0.117	-2.558	.005	.010	3	1
UCEC	GSK-3_pS9 →	+0.407	+1.700	.017	.044	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.512	+2.469	.004	.010	3	1
UCEC	Heregulin →	-0.146	-2.459	.005	.019	3	1
UCEC	INPP4B →	-0.305	-2.000	.026	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Akt_pT308 by PTHLH expression — UCEC

Explore this box plot interactively →