PTHLH

Across TCGA cell cohorts, PTHLH RNA expression is significantly associated with the go_rna of many other GO terms, with 4,860 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PTHLH-associated GO terms across cancer lineages are Negative regulation of chondrocyte development, Biological process involved in symbiotic interaction, and Viral process. Each is linked with PTHLH in more than 12 cancer types. Because this analysis shows association rather than direction, both PTHLH-to-partner and partner-to-PTHLH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chondrocyte development grouped by PTHLH-low versus PTHLH-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTHLH→partner) and Y-score (partner→PTHLH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of chondrocyte development →	+1.279	+4.388	.001	.001	3	13
BONE	Biological process involved in symbiotic interaction →	+0.092	+1.631	<.001	<.001	3	12
STOMACH	Viral process →	+0.110	+3.363	<.001	<.001	3	11
CNS	Wound healing →	+0.105	+2.162	<.001	.002	2	12
PANCREAS	Regulation of ubiquitin-dependent protein catabolic process →	+0.053	+2.591	.002	<.001	3	11
OESOPHAGUS	Regulation of chondrocyte development →	+1.076	+3.504	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,860 associations by consensus.

Negative regulation of chondrocyte development by PTHLH expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →