PTH2

Across TCGA patient cohorts, PTH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,945 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible PTH2-associated GO terms across cancer lineages are Double-strand break repair via break-induced replication, G2/MI transition of meiotic cell cycle, and Positive regulation of cell cycle phase transition. Each is linked with PTH2 in more than 8 cancer types. Because this analysis shows association rather than direction, both PTH2-to-partner and partner-to-PTH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Double-strand break repair via break-induced replication grouped by PTH2-low versus PTH2-high in HNSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTH2→partner) and Y-score (partner→PTH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	Double-strand break repair via break-induced replication →	+0.055	+0.109	<.001	<.001	3	9
KIRP	G2/MI transition of meiotic cell cycle →	+0.051	+0.090	<.001	<.001	3	9
STAD	Positive regulation of cell cycle phase transition →	+0.043	+0.170	<.001	<.001	3	8
STAD	Cell cycle DNA replication →	+0.036	+0.118	<.001	<.001	3	8
STAD	DNA unwinding involved in DNA replication →	+0.042	+0.176	<.001	<.001	3	8
ESCA	Pericentric heterochromatin formation →	+0.065	+0.091	<.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,945 associations by consensus.

Double-strand break repair via break-induced replication by PTH2 expression — HNSC

Explore this box plot interactively →