PTH2

Across TCGA patient cohorts, PTH2 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PTH2-associated genes across cancer lineages are MIR1185-1, RNU6-1124P, and RPS29P1. Each is linked with PTH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTH2-to-partner and partner-to-PTH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1185-1 grouped by PTH2-low versus PTH2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTH2→partner) and Y-score (partner→PTH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR1185-1 →	+0.465	+7.741	<.001	.009	3	1
STAD	RNU6-1124P →	+0.179	+5.070	<.001	.004	3	1
STAD	RPS29P1 →	+0.410	+4.254	.003	.008	3	1
SKCM	RNU6-832P →	+0.373	+7.816	<.001	.008	3	1
SKCM	RNU6-34P →	+0.318	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MIR1185-1 by PTH2 expression — COAD

Explore this box plot interactively →