PTH

Across TCGA patient cohorts, PTH RNA expression is significantly associated with the go_rna of many other GO terms, with 5,747 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PTH-associated GO terms across cancer lineages are Regulation of animal organ morphogenesis, Negative regulation of T cell proliferation, and Regulation of cysteine-type endopeptidase activity. Each is linked with PTH in more than 6 cancer types. Because this analysis shows association rather than direction, both PTH-to-partner and partner-to-PTH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of animal organ morphogenesis grouped by PTH-low versus PTH-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTH→partner) and Y-score (partner→PTH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Regulation of animal organ morphogenesis →	+0.072	+0.053	<.001	<.001	3	7
STAD	Negative regulation of T cell proliferation →	+0.042	+0.140	<.001	<.001	3	6
STAD	Regulation of cysteine-type endopeptidase activity →	+0.061	+0.155	<.001	<.001	3	6
TGCT	Mesoderm development →	+0.050	+0.083	<.001	<.001	3	6
TGCT	Negative regulation of Wnt signaling pathway →	+0.063	+0.047	<.001	<.001	3	6
STAD	Regeneration →	+0.044	+0.083	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,747 associations by consensus.

Regulation of animal organ morphogenesis by PTH expression — TGCT

Explore this box plot interactively →