PTH

Across TCGA cell cohorts, PTH RNA expression is significantly associated with the mutation status of many other genes, with 233 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PTH-associated genes across cancer lineages are TBX6, SLC20A2, and NRBP1. Each is linked with PTH in more than 1 cancer types. Because this analysis shows association rather than direction, both PTH-to-partner and partner-to-PTH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBX6 grouped by PTH-low versus PTH-high in SOFT_TISSUE.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTH→partner) and Y-score (partner→PTH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TBX6 →	+5.977	+0.083	.001	<.001	3	2
LUNG_NSCLC_LUAD	SLC20A2 →	+4.887	+0.045	.009	<.001	3	2
BLOOD_Lymphoma	NRBP1 →	+6.247	+0.023	<.001	<.001	3	2
BLOOD_Lymphoma	NETO2 →	+6.247	+0.023	<.001	<.001	3	2
LARGE_INTESTINE	LGMN →	+3.099	+0.033	.002	.001	3	2
LARGE_INTESTINE	USP37 →	+3.514	+0.046	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 233 associations by consensus.

TBX6 by PTH expression — SOFT_TISSUE

Explore this box plot interactively →