PTGS1

Across TCGA pan-cancer cohorts, PTGS1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PTGS1 data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher PTGS1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTGS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where PTGS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.729	0.954	.003	22	view →
CCRCC	OS	Tertile	All	0.587	1.000	.010	18	view →
HNSC	DFS	Median	All	0.854	0.350	.022	18	view →
GBM	OS	Tertile	All	0.979	0.703	.024	3	view →
UCEC	DFS	Tertile	All	0.791	0.950	.042	2	view →
LSCC	OS	Tertile	All	0.812	1.000	.026	2	view →
LUAD	OS	Median	II,III,IV	0.864	0.998	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PTGS1–PDAC (DFS)

Open the PDAC breakdown →