PTGS1

Across TCGA patient cohorts, PTGS1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGS1-associated genes across cancer lineages are 4E-BP1, GAPDH, and G6PD. Each is linked with PTGS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTGS1-to-partner and partner-to-PTGS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PTGS1-low versus PTGS1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGS1→partner) and Y-score (partner→PTGS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	4E-BP1 →	+0.314	+3.169	.017	.018	3	3
LUAD	GAPDH →	+0.521	+2.321	.026	.033	3	2
SKCM	G6PD →	-0.306	-3.152	<.001	.017	3	2
SKCM	Rab25 →	-0.298	-3.906	.006	<.001	3	2
SKCM	CD31 →	-0.245	-3.153	<.001	.018	3	2
UCEC	eIF4E →	+0.166	+3.013	.045	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

4E-BP1 by PTGS1 expression — LUAD

Explore this box plot interactively →