PTGS1

Across TCGA cell cohorts, PTGS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,542 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PTGS1-associated GO terms across cancer lineages are Cell-substrate junction assembly, Viral life cycle, and Epithelial cell fate commitment. Each is linked with PTGS1 in more than 7 cancer types. Because this analysis shows association rather than direction, both PTGS1-to-partner and partner-to-PTGS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell-substrate junction assembly grouped by PTGS1-low versus PTGS1-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGS1→partner) and Y-score (partner→PTGS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Cell-substrate junction assembly →	+0.115	+1.530	.004	.002	3	8
OESOPHAGUS	Viral life cycle →	+0.071	+2.023	.008	.001	3	8
BLOOD_Leukemia	Epithelial cell fate commitment →	+0.096	+1.683	<.001	<.001	3	8
STOMACH	Regulation of viral process →	+0.067	+1.423	.003	.007	3	8
SKIN	Positive regulation of protein localization to nucleus →	+0.082	+1.206	<.001	.003	3	7
BLOOD_Lymphoma	Negative regulation of respiratory burst involved in inflammatory response →	+0.117	+1.153	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,542 associations by consensus.

Cell-substrate junction assembly by PTGS1 expression — SKIN

Explore this box plot interactively →