PTGS1

Across TCGA cell cohorts, PTGS1 mutation is significantly associated with the RNA expression of many other genes, with 923 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTGS1-associated genes across cancer lineages are ASB17, GRXCR2, and OR2D2. Each is linked with PTGS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PTGS1-to-partner and partner-to-PTGS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by PTGS1-low versus PTGS1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGS1→partner) and Y-score (partner→PTGS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	2
LARGE_INTESTINE	GRXCR2 →	+0.032	+1.959	<.001	.003	2	3
LUNG_NSCLC_LUAD	OR2D2 →	+0.049	+3.977	.002	.005	3	1
LUNG_NSCLC_LUAD	DCDC2C →	+0.081	+3.760	<.001	.008	3	1
LUNG_NSCLC_LUAD	ZNF735 →	+0.027	+3.947	<.001	.004	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 923 associations by consensus.

ASB17 by PTGS1 expression — OVARY

Explore this box plot interactively →