PTGR2

Across TCGA pan-cancer cohorts, PTGR2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated PTGR2 data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PTGR2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PTGR2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, UCEC, and LSCC are the cancer types where PTGR2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.835	0.412	.002	19	view →
UCEC	OS	Tertile	III,IV	0.379	1.000	.016	12	view →
LSCC	DFS	Median	II,III,IV	0.485	1.000	.006	9	view →
PDAC	OS	Median	II,III,IV	0.913	0.738	.023	7	view →
COAD	DFS	Median	IV	0.432	0.944	.038	6	view →
GBM	DFS	Tertile	All	0.561	0.890	.011	6	view →
LUAD	DFS	Tertile	II,III,IV	0.775	0.954	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

PTGR2–CCRCC (DFS)

Open the CCRCC breakdown →