PTGR1

Across TCGA pan-cancer cohorts, PTGR1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PTGR1 data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PTGR1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTGR1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

HNSC, LUAD, and KIRC are the cancer types where PTGR1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.230	0.402	<.001	146	view →
LUAD	DFS	Tertile	All	0.720	0.844	.001	67	view →
KIRC	DFS	Median	All	0.715	0.545	<.001	56	view →
LGG	DFS	Median	All	0.655	0.822	<.001	54	view →
READ	DFS	Quartile	All	1.000	0.502	.002	40	view →
DLBC	DFS	Median	All	0.820	0.386	.001	33	view →
THCA	OS	Median	III,IV	1.000	0.904	.007	21	view →
MESO	DFS	Median	II,III,IV	0.498	0.304	.005	15	view →
SCLC	DFS	Tertile	IV	0.119	0.397	.006	15	view →
ESCA	DFS	Tertile	All	0.860	0.307	.014	12	view →
UCEC	OS	Median	All	0.781	0.607	.020	12	view →
ACC	DFS	Quartile	All	0.427	0.814	.002	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PTGR1–HNSC (DFS)

Open the HNSC breakdown →