PTGIS

Across TCGA pan-cancer cohorts, PTGIS mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PTGIS data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PTGIS mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTGIS expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

CCRCC, COAD, and LSCC are the cancer types where PTGIS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.105	0.952	<.001	35	view →
COAD	DFS	Median	All	0.889	1.000	.024	6	view →
LSCC	DFS	Median	All	0.929	0.615	.025	1	view →
PDAC	DFS	Median	III,IV	0.825	0.561	.017	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PTGIS–CCRCC (DFS)

Open the CCRCC breakdown →