PTGIS

Across TCGA patient cohorts, PTGIS protein abundance is significantly associated with the RNA expression of many other genes, with 16,445 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PTGIS-associated genes across cancer lineages are FGF7, MEDAG, and SFRP4. Each is linked with PTGIS in more than 8 cancer types. Because this analysis shows association rather than direction, both PTGIS-to-partner and partner-to-PTGIS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PTGIS versus FGF7 in OV, with a Pearson correlation of 0.79.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGIS→partner) and Y-score (partner→PTGIS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FGF7 →	+2.009	+1.131	<.001	<.001	3	9
OV	MEDAG →	+2.163	+1.112	<.001	<.001	3	8
OV	SFRP4 →	+2.314	+1.055	<.001	<.001	3	8
OV	CXCL12 →	+2.079	+1.111	<.001	<.001	3	8
OV	ACTA2 →	+2.289	+1.087	<.001	<.001	3	8
CCRCC	DCN →	+1.774	+0.549	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,445 associations by consensus.

PTGIS vs FGF7 — OV

Explore this scatter interactively →