PTGIS

Across TCGA patient cohorts, PTGIS mutation is significantly associated with the RNA expression of many other genes, with 3,114 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGIS-associated genes across cancer lineages are GUF1, SNX7, and H2AZ1. Each is linked with PTGIS in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGIS-to-partner and partner-to-PTGIS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GUF1 grouped by PTGIS-low versus PTGIS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGIS→partner) and Y-score (partner→PTGIS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GUF1 →	+0.483	+2.246	<.001	.005	3	2
UCEC	SNX7 →	+0.730	+3.716	.002	<.001	3	2
UCEC	H2AZ1 →	+0.664	+3.823	<.001	<.001	3	2
UCEC	KCNK5 →	-1.108	-2.715	<.001	<.001	3	2
UCEC	R3HCC1L →	+0.372	+2.708	.006	.003	3	2
UCEC	ADAMTS15 →	-1.403	-3.967	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,114 associations by consensus.

GUF1 by PTGIS expression — UCEC

Explore this box plot interactively →