PTGIS

Across TCGA patient cohorts, PTGIS mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGIS-associated genes across cancer lineages are 4E-BP1, A-Raf_pS299, and p27_pT198. Each is linked with PTGIS in more than 2 cancer types. Because this analysis shows association rather than direction, both PTGIS-to-partner and partner-to-PTGIS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by PTGIS-low versus PTGIS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGIS→partner) and Y-score (partner→PTGIS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.252	+3.169	.020	.018	3	3
UCEC	A-Raf_pS299 →	-0.110	-3.321	.022	.010	3	2
UCEC	p27_pT198 →	+0.096	+3.321	.026	.010	3	2
UCEC	STAT3_pY705 →	-0.344	-1.906	.001	.016	3	2
UCEC	INPP4B →	-0.259	-2.000	.046	.030	3	1
UCEC	JNK2 →	+0.214	+2.331	.007	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

4E-BP1 by PTGIS expression — UCEC

Explore this box plot interactively →