PTGIS

Across TCGA cell cohorts, PTGIS mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTGIS-associated genes across cancer lineages are MAGEB4, KRTAP17-1, and MYH1. Each is linked with PTGIS in more than 2 cancer types. Because this analysis shows association rather than direction, both PTGIS-to-partner and partner-to-PTGIS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by PTGIS-low versus PTGIS-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGIS→partner) and Y-score (partner→PTGIS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MAGEB4 →	+0.006	+5.087	<.001	.004	3	1
URINARY_TRACT	KRTAP17-1 →	+0.026	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUAD	MYH1 →	+0.016	+5.662	<.001	.002	3	1
BREAST	GRIFIN →	+0.109	+4.199	<.001	.007	3	1
BREAST	SCYGR10 →	+0.082	+4.781	<.001	.003	3	1
LUNG_SCLC	SMIM9 →	+0.037	+3.232	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

MAGEB4 by PTGIS expression — URINARY_TRACT

Explore this box plot interactively →