PTGIR

Across TCGA patient cohorts, PTGIR mutation is significantly associated with the RNA expression of many other genes, with 177 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGIR-associated genes across cancer lineages are LINC01072, HIGD1AP9, and CTAG1A. Each is linked with PTGIR in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGIR-to-partner and partner-to-PTGIR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01072 grouped by PTGIR-low versus PTGIR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGIR→partner) and Y-score (partner→PTGIR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01072 →	+0.290	+3.810	<.001	<.001	3	2
COAD	HIGD1AP9 →	+0.234	+5.321	.001	.001	3	2
COAD	CTAG1A →	+0.053	+6.409	<.001	<.001	3	2
LUAD	RPL21P88 →	+0.171	+4.293	<.001	.008	3	2
HNSC	LINC02191 →	+0.106	+6.111	<.001	.002	3	2
HNSC	CAPZA1P5 →	+0.059	+6.111	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 177 associations by consensus.

LINC01072 by PTGIR expression — UCEC

Explore this box plot interactively →