PTGIR

Across TCGA cell cohorts, PTGIR mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTGIR-associated genes across cancer lineages are TGM7, CCDC42, and SERPINB12. Each is linked with PTGIR in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGIR-to-partner and partner-to-PTGIR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TGM7 grouped by PTGIR-low versus PTGIR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGIR→partner) and Y-score (partner→PTGIR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TGM7 →	+0.025	+3.103	<.001	.004	3	1
LARGE_INTESTINE	CCDC42 →	+0.040	+2.925	<.001	.007	3	1
LARGE_INTESTINE	SERPINB12 →	+0.100	+3.145	<.001	.004	3	1
LARGE_INTESTINE	ADIPOQ →	+0.009	+3.217	<.001	.006	3	1
LARGE_INTESTINE	FSCB →	+0.002	+3.700	<.001	.009	3	1
LARGE_INTESTINE	BPIFA1 →	+0.171	+3.103	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

TGM7 by PTGIR expression — LARGE_INTESTINE

Explore this box plot interactively →