PTGIR

Across TCGA cell cohorts, PTGIR mutation is significantly associated with the mutation status of many other genes, with 1,112 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTGIR-associated genes across cancer lineages are MYO7A, TPCN2, and TTLL10. Each is linked with PTGIR in more than 2 cancer types. Because this analysis shows association rather than direction, both PTGIR-to-partner and partner-to-PTGIR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYO7A grouped by PTGIR-low versus PTGIR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGIR→partner) and Y-score (partner→PTGIR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MYO7A →	+1.799	+3.769	.002	.002	1	3
LARGE_INTESTINE	TPCN2 →	+2.407	+2.886	.008	.008	1	2
LARGE_INTESTINE	TTLL10 →	+3.215	+3.954	<.001	<.001	1	2
LARGE_INTESTINE	PLB1 →	+2.799	+4.635	<.001	<.001	1	2
LARGE_INTESTINE	EML5 →	+2.215	+4.169	<.001	<.001	1	2
LARGE_INTESTINE	ARHGEF40 →	+2.215	+3.247	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,112 associations by consensus.

MYO7A by PTGIR expression — LARGE_INTESTINE

Explore this box plot interactively →