PTGFRN

Across TCGA pan-cancer cohorts, PTGFRN mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PTGFRN’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PTGFRN mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PTGFRN is over-expressed in tumor, although a few such as COAD and OV show the opposite, repressed pattern.

COAD, LSCC, and LUAD are the cancer types where PTGFRN tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PTGFRN mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−1.041	<.001	11	view →
LSCC	All	III,IV	+0.900	<.001	9	view →
LUAD	All	All	+0.221	<.001	7	view →
HNSC	All	II,III,IV	+0.157	.023	4	view →
OV	All	All	−0.669	.020	2	view →
PDAC	All	All	−0.250	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PTGFRN–COAD

Open the COAD breakdown →