PTGFRN

Across TCGA patient cohorts, PTGFRN mutation is significantly associated with the RNA expression of many other genes, with 1,856 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGFRN-associated genes across cancer lineages are PSMB6, MTFP1, and TLCD3A. Each is linked with PTGFRN in more than 3 cancer types. Because this analysis shows association rather than direction, both PTGFRN-to-partner and partner-to-PTGFRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMB6 grouped by PTGFRN-low versus PTGFRN-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGFRN→partner) and Y-score (partner→PTGFRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PSMB6 →	+0.441	+2.920	.001	.001	3	4
COAD	MTFP1 →	+0.472	+2.933	.005	<.001	3	4
COAD	TLCD3A →	+0.531	+3.817	.001	<.001	3	3
UCEC	DDIT4 →	+0.877	+1.856	<.001	.004	3	3
UCEC	LETM1 →	+0.429	+2.191	<.001	.001	3	3
UCEC	ATPAF2 →	+0.339	+3.960	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,856 associations by consensus.

PSMB6 by PTGFRN expression — COAD

Explore this box plot interactively →