PTGFRN

Across TCGA cell cohorts, PTGFRN mutation is significantly associated with the RNA expression of many other genes, with 295 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PTGFRN-associated genes across cancer lineages are UBQLN3, MS4A14, and SPACA3. Each is linked with PTGFRN in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGFRN-to-partner and partner-to-PTGFRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBQLN3 grouped by PTGFRN-low versus PTGFRN-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGFRN→partner) and Y-score (partner→PTGFRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	UBQLN3 →	+0.006	+5.754	<.001	.002	3	2
SOFT_TISSUE	MS4A14 →	+0.081	+4.930	<.001	.008	3	1
LUNG_SCLC	SPACA3 →	+0.135	+3.070	<.001	.009	3	1
LUNG_SCLC	IFNL1 →	+0.136	+3.938	<.001	<.001	3	1
LUNG_SCLC	OR6M1 →	+0.109	+3.232	<.001	.008	3	1
LUNG_NSCLC_LUAD	TSHB →	+0.052	+3.189	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 295 associations by consensus.

UBQLN3 by PTGFRN expression — CNS

Explore this box plot interactively →