PTGFR

Across TCGA patient cohorts, PTGFR mutation is significantly associated with the RNA expression of many other genes, with 3,334 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGFR-associated genes across cancer lineages are DHDDS, DNAJC7, and MIR3681. Each is linked with PTGFR in more than 2 cancer types. Because this analysis shows association rather than direction, both PTGFR-to-partner and partner-to-PTGFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DHDDS grouped by PTGFR-low versus PTGFR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGFR→partner) and Y-score (partner→PTGFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DHDDS →	+0.307	+1.726	.001	.002	3	3
UCEC	DNAJC7 →	+0.409	+2.210	<.001	.001	3	3
BRCA	MIR3681 →	+0.833	+8.471	<.001	.005	3	2
LIHC	TRAJ47 →	+0.679	+6.479	<.001	.001	3	2
UCEC	ZNHIT3 →	+0.376	+2.343	.002	<.001	3	2
UCEC	TAF9 →	+0.616	+2.321	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,334 associations by consensus.

DHDDS by PTGFR expression — UCEC

Explore this box plot interactively →