PTGFR

Across TCGA patient cohorts, PTGFR mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGFR-associated genes across cancer lineages are Caspase-8, Cyclin-B1, and FoxM1. Each is linked with PTGFR in more than 2 cancer types. Because this analysis shows association rather than direction, both PTGFR-to-partner and partner-to-PTGFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by PTGFR-low versus PTGFR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGFR→partner) and Y-score (partner→PTGFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.180	-3.558	.042	.002	3	2
SKCM	Cyclin-B1 →	+0.570	+3.087	<.001	<.001	2	3
SKCM	FoxM1 →	+0.252	+2.321	.002	.032	3	2
SKCM	ACC1 →	+0.341	+2.321	.005	.032	3	2
SKCM	Ku80 →	+0.288	+1.906	.009	.016	3	2
SKCM	STAT3_pY705 →	-0.247	-2.584	.022	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Caspase-8 by PTGFR expression — UCEC

Explore this box plot interactively →