PTGFR

Across TCGA cell cohorts, PTGFR mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PTGFR-associated genes across cancer lineages are PRSS58, PNLIP, and OR2T35. Each is linked with PTGFR in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGFR-to-partner and partner-to-PTGFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS58 grouped by PTGFR-low versus PTGFR-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGFR→partner) and Y-score (partner→PTGFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
BLOOD_Myeloma	PNLIP →	+0.046	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR2T35 →	+0.086	+4.807	<.001	.006	3	1
BLOOD_Myeloma	TPRX1 →	+0.006	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR2A5 →	+0.040	+4.807	<.001	.006	3	1
BLOOD_Myeloma	H3C11 →	+0.416	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

PRSS58 by PTGFR expression — PANCREAS

Explore this box plot interactively →