Across TCGA pan-cancer cohorts, PTGES3P5 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of PTGES3P5’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PTGES3P5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PTGES3P5 is over-expressed in tumor.
KIRC are the cancer types where PTGES3P5 tumor–normal differential expression is most reproducible.