PTGES3L

Across TCGA pan-cancer cohorts, PTGES3L RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PTGES3L data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher PTGES3L RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PTGES3L expression acts as an unfavorable survival marker, although some lineages such as PAAD and LUSC show a favorable association.

KICH, KIRC, and MESO are the cancer types where PTGES3L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	III,IV	0.398	1.000	<.001	104	view →
KIRC	OS	Tertile	All	0.531	0.703	.001	68	view →
MESO	OS	Tertile	All	0.410	0.662	.001	57	view →
PAAD	DFS	Tertile	All	0.486	0.259	.002	52	view →
LUSC	OS	Quartile	All	0.846	0.668	<.001	45	view →
UVM	DFS	Tertile	All	0.414	0.807	.007	40	view →
LIHC	DFS	Tertile	All	0.414	0.668	.004	38	view →
UCEC	DFS	Quartile	II,III,IV	0.874	0.731	.011	36	view →
KIRP	DFS	Tertile	All	0.949	0.857	.011	19	view →
ESCA	OS	Tertile	IV	0.856	0.219	.024	18	view →
LGG	DFS	Median	All	0.674	0.798	<.001	17	view →
UCS	DFS	Quartile	II,III,IV	0.603	0.183	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PTGES3L–KICH (OS)

Open the KICH breakdown →