PTGES3L-AARSD1

Across TCGA pan-cancer cohorts, PTGES3L-AARSD1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PTGES3L-AARSD1 data layer compared with 2 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PTGES3L-AARSD1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PTGES3L-AARSD1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and LUSC show a favorable association.

UVM, SCLC, and THCA are the cancer types where PTGES3L-AARSD1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.393	0.782	<.001	108	view →
SCLC	OS	Quartile	II,III,IV	0.433	0.776	.003	64	view →
THCA	DFS	Tertile	II,III,IV	0.643	0.904	.004	63	view →
LGG	DFS	Median	All	0.663	0.807	<.001	54	view →
LIHC	OS	Tertile	All	0.695	0.830	.002	45	view →
COAD	DFS	Quartile	All	0.652	0.848	.001	24	view →
KIRC	OS	Quartile	All	0.826	0.897	.010	23	view →
ESCA	OS	Tertile	IV	0.856	0.219	.024	20	view →
LUSC	OS	Median	II,III,IV	0.480	0.325	.013	20	view →
MESO	DFS	Quartile	All	0.247	0.787	.026	18	view →
BLCA	DFS	Quartile	II,III,IV	0.419	0.577	.003	17	view →
KIRP	DFS	Quartile	All	1.000	0.854	.003	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PTGES3L-AARSD1–UVM (DFS)

Open the UVM breakdown →