PTGES3

Across TCGA patient cohorts, PTGES3 mutation is significantly associated with the RNA expression of many other genes, with 463 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGES3-associated genes across cancer lineages are LINC01941, SLC7A11, and TMEM263. Each is linked with PTGES3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGES3-to-partner and partner-to-PTGES3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01941 grouped by PTGES3-low versus PTGES3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGES3→partner) and Y-score (partner→PTGES3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	LINC01941 →	+0.145	+4.669	<.001	.007	3	2
UCEC	SLC7A11 →	+0.987	+3.337	.001	.005	3	1
UCEC	TMEM263 →	+0.582	+3.202	.006	.009	3	1
UCEC	JAKMIP1 →	+0.573	+2.818	.003	.001	3	1
UCEC	SRP19 →	+0.567	+2.807	<.001	.003	3	1
UCEC	HEATR3 →	+0.552	+3.329	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 463 associations by consensus.

LINC01941 by PTGES3 expression — CESC

Explore this box plot interactively →