PTGES3

Across TCGA patient cohorts, PTGES3 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGES3-associated genes across cancer lineages are JNK2, VHL, and 4E-BP1_pT37_T46. Each is linked with PTGES3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGES3-to-partner and partner-to-PTGES3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PTGES3-low versus PTGES3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGES3→partner) and Y-score (partner→PTGES3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.185	+2.817	.045	.036	3	1
UCEC	VHL →	-1.016	-3.321	.001	.010	3	1
UCEC	4E-BP1_pT37_T46 →	-0.540	-2.584	.001	.011	3	1
UCEC	Caspase-7-cleavedD198 →	+1.052	+2.584	<.001	.011	3	1
UCEC	c-Met_pY1235 →	+0.078	+3.179	.023	.010	3	1
UCEC	MEK1 →	+0.422	+3.000	.013	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

JNK2 by PTGES3 expression — UCEC

Explore this box plot interactively →