PTGES3

Across TCGA cell cohorts, PTGES3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,188 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PTGES3-associated GO terms across cancer lineages are DNA replication initiation, Protein localization to kinetochore, and Mitotic DNA replication checkpoint signaling. Each is linked with PTGES3 in more than 16 cancer types. Because this analysis shows association rather than direction, both PTGES3-to-partner and partner-to-PTGES3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication initiation grouped by PTGES3-low versus PTGES3-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGES3→partner) and Y-score (partner→PTGES3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DNA replication initiation →	+0.175	+0.952	.001	.009	3	17
UPPER_AERODIGESTIVE_TRACT	Protein localization to kinetochore →	+0.166	+1.195	<.001	<.001	3	17
BONE	Mitotic DNA replication checkpoint signaling →	+0.193	+0.813	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.130	+1.262	<.001	<.001	3	16
BONE	DNA replication checkpoint signaling →	+0.174	+0.812	.004	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Spermine biosynthetic process →	+0.195	+1.037	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,188 associations by consensus.

DNA replication initiation by PTGES3 expression — BLOOD_Myeloma

Explore this box plot interactively →