PTGES2

Across TCGA patient cohorts, PTGES2 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PTGES2-associated genes across cancer lineages are Fibroblasts, CD8+ Tem, and CD4+ naive T-cells. Each is linked with PTGES2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PTGES2-to-partner and partner-to-PTGES2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibroblasts grouped by PTGES2-low versus PTGES2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGES2→partner) and Y-score (partner→PTGES2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	Fibroblasts →	+0.013	+5.339	.036	.047	3	1
UCEC	CD8+ Tem →	+0.004	+4.744	<.001	.040	3	1
UCEC	CD4+ naive T-cells →	+0.010	+2.682	<.001	.048	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Fibroblasts by PTGES2 expression — HNSC

Explore this box plot interactively →