PTGES2

Across TCGA cell cohorts, PTGES2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,786 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PTGES2-associated GO terms across cancer lineages are Transcription pausing by RNA polymerase II, Protein-DNA complex disassembly, and CTP salvage. Each is linked with PTGES2 in more than 14 cancer types. Because this analysis shows association rather than direction, both PTGES2-to-partner and partner-to-PTGES2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription pausing by RNA polymerase II grouped by PTGES2-low versus PTGES2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PTGES2→partner) and Y-score (partner→PTGES2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Transcription pausing by RNA polymerase II →	+0.172	+0.875	<.001	<.001	3	15
BONE	Protein-DNA complex disassembly →	+0.178	+1.059	<.001	<.001	3	14
URINARY_TRACT	CTP salvage →	+0.118	+1.110	<.001	<.001	3	14
BONE	Nucleosome disassembly →	+0.216	+1.064	<.001	<.001	3	13
BONE	Mitochondrial tRNA pseudouridine synthesis →	+0.170	+1.191	<.001	<.001	3	13
URINARY_TRACT	rRNA pseudouridine synthesis →	+0.133	+1.140	<.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,786 associations by consensus.

Transcription pausing by RNA polymerase II by PTGES2 expression — BONE

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